Breast syndromes

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Breast cancer is now the most common cancer in most cities in India. In some families, clusters of individuals with breast cancers are seen across and through one or two generations. Such cancers are called hereditary cancers and known to be associated with inherited gene mutations.

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Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults. The cancers most often associated with Li-Fraumeni syndrome include breast cancera form of bone cancer called osteosarcoma, and cancers of soft tissues such as muscle called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues leukemiasand a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands small hormone-producing glands on top of each kidney.

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This material supplements information provided by physicians, nurses, genetic counselors, and other members of your health care team about Cowden syndrome. It does not replace regular medical care or discussions with your health care team. If you see an unfamiliar term, please see the Glossary of Terms at the end of this material.

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Sometimes, certain types of cancer seem to run in some families. In some cases, this might be because family members share certain behaviors or exposures that increase cancer risk, such as such as smoking. Cancer risk might also be affected by other factors, like obesity, that tend to run in some families. But in some cases the cancer is caused by an abnormal gene that is being passed along from generation to generation.

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Hereditary breast and ovarian cancer HBOC syndrome is an inherited cancer-predisposition syndrome. Affected individuals have a significantly greater risk of developing certain cancers, particularly breast cancer, in both men and women, and ovarian cancer in women. Affected individuals tend to develop cancer earlier in life as well, usually before the age of

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Poland syndrome is a birth defect characterized by an underdeveloped chest muscle and short webbed fingers on one side of the body. The cause is unknown. Treatment depends on the severity and may include surgical correction.

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Skip to site alert. Skip to content. The two genes were previously known to cause Lynch syndrome, an inherited condition that raises the risk of colorectal, ovarian, stomach, and endometrial cancer.

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Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts ductal cancer. In women, cancer can also develop in the glands that produce milk lobular cancer.

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Hereditary breast—ovarian cancer syndromes HBOC are cancer syndromes that produce higher than normal levels of breast cancerovarian cancer and additional cancers in genetically related families either one individual had both, or several individuals in the pedigree had one or the other disease. In reality, all sexes have the same rates of gene mutations and HBOC can predispose to other cancers including prostate cancer and pancreatic cancer. A number of genes are associated with HBOC.

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Identify the most important clinical genetic syndromes that increase the risk of hereditary breast cancer. Describe surgical management options that reduce the risk of developing hereditary breast cancer. Outline the risks and benefits of using chemopreventative interventions in carriers of genetic mutations that increase the risk of hereditary breast cancer.

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